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KMID : 1140120120170010019
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Cancer Prevention Research
2012 Volume.17 No. 1 p.19 ~ p.26
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Apoptotic Effects of Curcumin via the Regulation of COX-2/VASP Signaling Molecules in MCF-7 Breast Cancer Cells
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Lee Se-Hee
Lee Gi-Ho
Park Song-Yi
Lee Sol-Hwa
Koo Bong-Seong
Park Ock-Jin
Kim Young-Min
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Abstract
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Curcumin, a phytochemical acquired to yellow curry, has potent anti-inflammatory and anti-oxidant activities. Cyclooxygenase-2 (COX-2) is inducible enzymes, and regulates the level of prostaglandins during inflammation. A vasodilatator-stimulated phosphoprotein (VASP) is connected to actin, and is activated by phosphorylation. In this study, we investigated the effect of curcumin on apoptosis and COX-2/VASP signaling pathway. We observed that curcumin inhibited cell proliferation and caused apoptosis in MCF-7 breast cancer cells. Treatment of compound C, an AMPK inhibitor, resulted in increased cell proliferation of cancer cells and showed that COX-2 and VASP are regulated by AMPK. Also, the co-treatment with celecoxib (COX-2 inhibitor) and curcumin resulted in decreased cell proliferation in breast cancer cells. Inhibition of COX-2 was regulated by the expression of VASP, indicating that the COX-2/VASP signaling molecules played an important role for apoptosis in MCF-7 breast cancer cells. In conclusion, curcumin had anti-proliferative and apoptotic effects through the regulation of COX-2 and VASP signal pathway.
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KEYWORD
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Curcumin, COX-2, VASP, MCF-7 breast cancer cells, Apoptosis
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